Chiralizer™ Services, L.L.C. was founded by William Letter in 1993 to provide innovative solutions to the problems faced by analytical chemists in the pharmaceutical research industry. Our products can be found in ever major pharmaceutical company in the world. *We are a U.S. Department of Defense (CCR) listed contractor. Chiralizer™ Services currently offers the following products and services :

• A unique line of proprietary HPLC, UHPLC and LC-MS automation products.
  • The LC Spiderling™ line of Automated HPLC Column Selectors
  • The Column Swapper™ Alternating Column Regeneration System
  • The LC Sample Peak Recycler™ Analytical Recycle HPLC System
  • The LC-MS Watchdog™ Source Contamination Minimizer
  • The 2D Multidimensional Column Switching System for LC x LC HPLC

• Expert Chiral HPLC Method Development Consulting in:
  • Analytical % e.e. determination
  • Racemic chiral HPLC and SFC method development

• Agilent Technologies / Hewlett-Packard brand analytical HPLC and LC-MS:
  • Instrument installation & site preparation
  • Instrument qualification and performance verification (IQ, OQ, PV)
  • Instrument operation, repair and maintenance services classes
  • Advanced ChemStation for HPLC and LC-MS operation and servicing training classes
  • Expert training in the use of the HP and/or Agilent 1090, 1050, 1100, 1200, 1260 and 1290-Series HPLC systems

• A number of areas of scientific consulting, including :
  • General HPLC, UHPLC and LC-MS consulting, including the set up of new labs, the improvement of existing operations and assistance with complex separation, method development or instrumentation problems - regardless of equipment manufacturer.
  • Diverse customized training classes for individuals or groups in a number of diverse analytical areas, including chiral method development, automated HPLC method development, instrument performance verification, polymer characterization, MW determination, peptide and protein resolution and data station operation.

• New and Reconditioned HPLC Instruments and Computers :
  • HPLC modules and systems, LC-MS systems, Spectrophotometers, HP Computers, NetServers, Printers and Plotters. Please Check our most recent Inventory Listing.

The proprietary products of Chiralizer™ Services have been designed to automate common procedures used in HPLC and LC-MS analyses. Chiralizer™ Services developed the popular LC SPIDERLING ™ Automated Column Selection System - now used by most of the world's major pharmaceutical, chemical and environmental companies to achieve greater efficiencies in both sample testing, throughput and in the development of new test methods.

The company's name is derived from the first application of the LC SPIDERLING™ in the form of an  intelligent, automated method development device for chiral HPLC separations. The original "Chiralizer™", as it was known, (Short for automated chiral screening analyzer) was used to screen racemic samples against a number of proven commercial chiral columns and mobile phases. Within six months, it enabled the elimination of a backlog of over 600 chiral compounds waiting for separation methods. To date, over ten thousand unique chiral methods have been developed using the product for chiral analysis in our laboratory alone.

Because it could automate the method development and analysis process for most non-chiral (achiral) as well as chiral samples, the Chiralizer's name was changed to the "LC SPIDERLING™" (it's  plumbing resembles a spiders body and legs), and it became the first in a growing series of proprietary automation & control devices offered to chemist's.

Chiralizer™ Services, L.L.C. operates from offices located in the Greater Philadelphia area at 12 Penn's Trail, Newtown, PA  18940   USA.

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